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Concomitantly administration of Loratadine with ketoconazole, erythromycin, clarithromycin, cimetidine, quinidine, fluoxetine may increase plasma concentration of both Loratadine and active metabolite.
Concomitantly administration of Loratadine with HIV protease inhibitors such as amprenavir, ritonavir, nelfinavir may increase plasma level of Loratadine.
Concomitantly administration of Loratadine with citalopram, diazepam, methsuximide, phenytoin, propranolol, sertraline, and any other CYP2C19 substrates may increase effect or serum levels of adjacent drugs.
Concomitantly administration of Loratadine with alcohol may increase risk of CNS depression.
Concomitantly administration of Loratadine with St. John's wort may decrease Loratadine levels.
